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Anabolic oral steroids put stress on the liver. Not all of them has the same negative impact however all 17A oral steroids will affect in a way your liver. 17 alpha alkylation refers to the addition of an alkyl group (either a methyl or ethyl) to the alpha position of the 17 carbon in the steroid backbone. By adding this methyl group at the 17a position the major route of androgen deactivation is avoided. The additional methyl stops the oxidation of the steroid to a 17-keto steroid. This allows a large part of the steroid to avoid the first pass metabolism and degradation in the liver.
How important is my liver?
The liver is such an important organ that we can only survive one or two days if it shuts down—if the liver fails, your body will fail too. Fortunately, the liver can function even when 75% of it is diseased or removed. This is because it has the amazing ability to create new liver tissue (i.e. it can regenerate itself) from healthy liver cells that still exist.
In this group are steroids such as: Dbol (Methandrostenolone), Oxymetholone, Methyltestosterone, Oxandrolone.
It is worth mentioning that not every bodybuilder is affected by the use of these steroids.
I mean not every user will feel negative impact. There are people who may take orals for many years and their health will not be affected. In the same time there are bodybuilders who will do a cycle of orals and they will feel small pains in liver’s region.
If you are from second group then better avoid using orals and use injectables steroids as they will not affect your liver in such measure as orals do.
However if you need using orals then better to keep your liver health then after to treat it.
For this there are supplements such as LIV 52 and Milk Thistle,Essentiale and other products which can be found on Internet.
Both are those products which will help you mantain your liver healthy.
Milk Thistle –
Milk thistles are thistles of the genus Silybum Adans., flowering plants of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name “milk thistle” derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap. However, it is the seeds of milk thistle that herbalists have used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.
Research suggests that milk thistle extracts both prevent and repair damage to the liver from toxic chemicals and medications. Workers who had been exposed to vapors from toxic chemicals (toluene and/or xylene) for 5-20 years were given either a standardized milk thistle extract (80% silymarin) or placebo for 3 years. The workers taking the milk thistle extract showed significant improvement in liver function tests (ALT and AST) and platelet counts vs. the placebo group.
The efficacy of silymarin in preventing drug-induced liver damage in patients taking psychotropic drugs long-term has been investigated . This class of drugs is known to cause liver damage from oxidation of lipids. Patients taking silymarin in the study had less hepatic damage from the oxidation of lipids than patients taking the placebo.
Liv-52 is a unique, all-natural, complex multi-ingredient formula. It is safe and effective in portecting the liver against harmful toxins from drugs, alcohol, food and water. Liv52 helps regulate levels of enzymes and optimizes assimilation. Liv-52 ( Liv52 ) has also been found to be associated with an increase in serum albumin, which is another indication of the liver protection it provides. Recent work shows that Liv52 has cholesterol-regulating action. Clinically, it helps maintain healthy levels of serum cholesterol, lipoproteins, phospholipids and triglycerides.
Liv-52 restores the functional efficiency of the liver by protecting the hepatic parenchyma and promoting hepatocellular regeneration. The antiperoxidative activity of Liv-52 prevents the loss of functional integrity of the cell membrane, maintains cytochrome P-450, hastens the recovery period and ensures early restoration of hepatic functions in infective hepatitis. Liv-52 facilitates rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and ensures protection from alcohol-induced hepatic damage. Liv-52 diminishes the lipotropic activity in chronic alcoholism, and prevents fatty infiltration of the liver. In pre-cirrhotic conditions,
Liv-52 arrests the progress of the disease and prevents further liver damage.Essentiale - is a preparation of essential phospholipids. Essentiale normalizes the metabolism of lipids and proteins, improves the detoxification function of the liver, restores the cellular structure of the liver and retards the producing of conjuctive tissue. Essentiale medications are indicated for the treatment of fatty degeneration of the liver, hepatitis (including toxic hepatitis, liver damage caused by medicines or alcohol abuse), cirrhosis of the liver, disturbances in liver function associated with different illnesses.
Why it is important to take breaks between steroid cycles for overall benefits. A few more advices on how use steroids wise and with less damage for your body.
Bacteriostatic Water vs. Sterile Water What is the difference and which one to use with HCG? Read this article to find out the differences between these two.
QUESTION: For 1 year I have used testosterone at 1ml/week together with HCG at 250 IU EOD now my testistcles are small and shrinked. Doctor say the shrinkage is not so bad. I do not want my balls to shrink or loose my ability to produce testosterone. Please help.